Module Catalogues, Xi'an Jiaotong-Liverpool University   
 
Module Code: BIO104
Module Title: Molecular Biology Principles
Module Level: Level 1
Module Credits: 2.50
Academic Year: 2019/20
Semester: SEM2
Originating Department: Biological Sciences
Pre-requisites: N/A
   
Aims
This module aims to provide a molecular understanding of the information processing pathways in the cell that lead to the expression of the genetic information in DNA. The structures and functions of the major components of these pathways, the proteins and nucleic acids, will be explained. DNA replication and its mutation and how gene expression is regulated will be introduced.
Learning outcomes 
A. gain knowledge in the essential elements of protein and nucleic acid structure.

B. understand the mechanisms of synthesis of DNA, RNA and proteins.

C. master DNA mutation and DNA repair.

D. obtain knowledge in the principles of gene expression and its regulation.

E. acquire the ability to apply, evaluate and interpret this knowledge to solve problems in biology.

Method of teaching and learning 
Course content will be delivered primarily via standard lectures, that will be accompanied by suitable lecture handouts (also available on the Web). Students will also be guided to sections of specific textbooks and if reading of specific reviews or sources literature is required then copies of these will be made available in the library for use by the students. At intervals during the module, revision lectures/exercises (up to 3 per module) will allow the students to self-assess their understanding of the course.
Syllabus 
Proteins: structure and function


- Basic structure and properties: amino acids, primary structure, covalent and non-covalent interactions, ionic and hydrophobic properties.


-dimensional structure: folding, conformation, denaturation, secondary, tertiary and quaternary structures.


- Diversity of protein structure and function: importance of shape - structure-function relationships, globular proteins, transport proteins, antibodies, enzymes, structural proteins (collagen, keratin).


Nucleic acids and information processing


- Primary structure: structures of bases, sugars, nucleosides and nucleotides. Base sequences.

Secondary and higher structures: the double helix, supercoiling, chromatin, different forms of RNA


- DNA replication: the cell cycle, replicons and origins, semi-conservative, semi-discontinuous mechanism, enzymology.


- Mutagenesis and DNA repair: fidelity of DNA replication, molecular nature of mutations, DNA damaging agents in the environment, DNA repair processes, human DNA repair disorders.


- Transcription: principles, RNA polymerases, transcription factors, RNA processing.


- Translation: the genetic code, stages of protein synthesis, post-translational modifications.


- Control of gene expression: the operon concept, the lac operon, catabolite repression, higher organisms and development.

Delivery Hours  
Lectures Seminars Tutorials Lab/Prcaticals Fieldwork / Placement Other(Private study) Total
Hours/Semester 20     2      53  75 

Assessment

Sequence Method % of Final Mark
1 Final Exam 70.00
2 Cw 30.00

Module Catalogue generated from SITS CUT-OFF: 5/23/2019 5:38:23 AM