Module Catalogues, Xi'an Jiaotong-Liverpool University   
Module Code: BIO203
Module Title: Microbiology and Virology
Module Level: Level 2
Module Credits: 5.00
Academic Year: 2019/20
Semester: SEM1
Originating Department: Biological Sciences
Pre-requisites: N/A
This module provides an introduction to both the diversity of pathogens that infect human and plants, and the features of such organisms that enable them to cause disease and resist host defense mechanisms. The major focus is on these interactions at the molecular level. The module takes a thematic approach, addressing the topic from the perspectives of both the pathogen and the microbiologist. Exemplar groups of pathogens are covered in more detail by means of case studies.

The course also provides an introduction to modern Virology. It aims to teach the fundamental basis of the virus life style, the relationship between study of viruses and the development of molecular biology problems associated with viruses and their control, and positive applications of viruses.
Learning outcomes 
A.understand and explain the concepts and principles of the main routes of transmission between hosts;

B. understand and explain the concepts and principles of the major components of host defense relevant to disease processes in humans and plants, and how pathogens evade these;

C. understand and explain the concepts and principles of the use of standard laboratory tests to identify bacterial and fungal pathogens;

D. understand and explain the concepts and principles of the role, development and current limitations of chemotherapy and immunization.

E. understand and explain the concepts and principles of the comparative behavior of bacterial, plant and animal viruses.

F. understand and explain the concepts and principles of the structure and life cycle properties of viruses.

G. understand and explain the concepts and principles of phenotypic and molecular effects of infections and how to identify and propagate viruses.

H. understand and explain the concepts and principles of the problems posed by viruses and measures for virus control.

I. understand and explain the concepts and principles of applications of viruses in medicine, molecular biology, biotechnology and biological control.

J. Students should also have acquired the ability to apply, evaluate and interpret this knowledge to solve problems in Biology.

K. Exhibit scientific writing skills including proper citing.
Method of teaching and learning 
Course content will be delivered primarily via standard lectures, that will be accompanied by
suitable lecture handouts (also available on the VLE). Students will also be guided to sections
of specific textbooks and if reading of specific reviews or other literature sources is required then copies of these will be made available to the students. At intervals during the module, revision lectures/exercises (up to 2 per module) will allow the students to self assess their understanding of the course. To accomplish learning outcome K, the students will be required to write a small paper including proper citing based on a review of scientific literature.

- Basic concepts: human pathogen, microbial pathogenicity, historical perspectives, interplay between host and pathogen.

- Epidemiology and emerging diseases. Principal modes of disease transmission and control methods for specific infections. Host, pathogen and environmental factors that affect emergence of disease.

- Diagnostics: approaches based on culture, biochemical and molecular properties. Principles and practice of biological safety.

- Defense mechanisms of plants and animals against pathogens. Fungicides and development of resistance. Non-acquired host defenses.

- Innate immunity: phagocytes, Toll-Like Receptors and C-type Lectin Receptors, the complement pathway.

- Acquired immunity: the humoral response (antigens and epitopes), the role of antibodies and clonal expansion and memory.

- Virulence factors: escape from the innate immune system, lipopolysaccharide, capsule, Ig proteases, chemotaxis inhibition, invasion of host cells, antigenic variation, secreted enzymes and toxins, classification of toxins and structure-function relationship.

- Vaccines: mode of action, types and examples, problems and future developments.

- Antibiotics. Sources, assay and modes of action, resistance mechanisms, drug development and future strategies.


 Virus replication and assembly

 Virus and host: Host range/barriers to infection

 Epidemiology, control, and diagnosis of animal virus infections

 Plant viruses

 Poxviruses

 Herpes Viruses

 Picornaviruses

 Orthomyxoviruses including influenza viruses

 Retroviruses and HIV

 Hepatitis Viruses

 Viruses and Cancer

 New and Emerging Viruses

 RNA phages & DNA phages: Lysogeny and phage conversion; Control of virus expression - Genome strategies

Delivery Hours  
Lectures Seminars Tutorials Lab/Prcaticals Fieldwork / Placement Other(Private study) Total
Hours/Semester 52    2+2      94  150 


Sequence Method % of Final Mark
1 Coursework Microbiology 15.00
2 Coursework Virology 15.00
3 Final Exam Microbiology And Virology 70.00

Module Catalogue generated from SITS CUT-OFF: 5/23/2019 5:40:04 AM