Module Catalogues, Xi'an Jiaotong-Liverpool University   
 
Module Code: BIO208
Module Title: Cell Signalling
Module Level: Level 2
Module Credits: 2.50
Academic Year: 2019/20
Semester: SEM2
Originating Department: Biological Sciences
Pre-requisites: N/A
   
Aims
This module will examine the molecular mechanisms that allow cells to communicate with each other. The basic properties common to all signalling pathways will be studied and then a series of individual pathways will be examined in more detail, in the light of these general principals. The importance of cellular signalling mechanisms will be illustrated by examining diseases (e.g. cancer) that result from defects in those mechanisms.
Learning outcomes 
A. To learn the common features shared by different means of communication between cells.

B. To understand the molecular mechanisms of the major cell-signalling pathways.

C. To acquire the knowledge of the ways in which different cell-signalling pathways may be integrated.

D. To obtain basic knowledge of the involvement of defective cell-signalling in diseases such as cancer.

E. To understand how the signalling principles have been developed and applied to other areas of biology, and know the methods and appropriate approaches required to solve problems in this area.



Method of teaching and learning 
Course content will be delivered primarily via standard lectures, that will be accompanied by suitable lecture handouts. Students will also be guided to sections of specific textbooks and/or reading of specific reviews.
Syllabus 
Topic 1 Communication between cells: Why do cells need to communicate with each other. The essential components of a cell signalling system.


Topic 2 Receptors, their basic functions and mechanisms of action. Different classes of signalling molecule.



Topic 3 Different mechanisms for different messengers. cAMP - the classic secondary messenger, G-proteins, adenylyl cyclase, phosphodiesterases, cAMP-dependent protein kinase. CREB and gene expression.



Topic 4 cGMP - Guanylyl cyclase and phosphodiesterase. Visual transduction. NO – a gaseous second messenger, other unusual messengers - superoxide, hydrogen peroxide and carbon monoxide.



Topic 5 Inositol trisphosphate and diacylglycerol as secondary messengers, Ca2+ release from intracellular stores, calmodulin & Ca2+ oscillations, PKC and calmodulin-dependent protein kinases.



Topic 6 Revision.



Topic 7 Receptor tyrosine kinases - phosphotyrosines as docking sites for SH2 domains, adaptor proteins, Ras activation, MAP kinase cascades, transcription factor activation.



Topic 8 Receptor dimerization and cross- phosphorylation, growth hormone, JAK2 - a cytosolic tyrosine kinase, STAT dimerization and activation of transcription.



Topic 9 Extracellular modulation of cell signalling complexes - I.



Topic 10 Extracellular modulation of cell signalling complexes - II.



Topic 11 Steroid hormone action, nuclear receptors and gene expression.



Topic 12 Revision and self-assessment of secondary messenger systems, key features -cascades, amplification, cross-talk, flexibility, adaptability.



Topic 13 Phases of the cell cycle, cdk complexes, protein phosphorylation and degradation control passage through the cell cycle.



Topic 14 MPF/mitotic cyclin B: ubiquitin-mediated degradation of mitotic cyclin; APC and degradation of cyclin B and exit from mitosis.



Topic 15 Intracellular effects of mitotic cyclin B: nuclear envelope breakdown, chromosome condensation, Golgi/ER breakdown, spindle formation; APC-induced chromosome degradation.



Topic 16 Multiple cyclins and cdks regulate the mammalian cell cycle.



Topic 17 Check points in cell cycle regulation.



Topic 18 Summary and conclusions; revision questions; exam technique.


Delivery Hours  
Lectures Seminars Tutorials Lab/Prcaticals Fieldwork / Placement Other(Private study) Total
Hours/Semester 26           49  75 

Assessment

Sequence Method % of Final Mark
1 Continuous Assessment 15.00
2 Final Exam 85.00

Module Catalogue generated from SITS CUT-OFF: 8/24/2019 3:36:48 PM