Module Catalogues, Xi'an Jiaotong-Liverpool University   
Module Code: BIO301
Module Title: Biology of Disease
Module Level: Level 3
Module Credits: 5.00
Academic Year: 2020/21
Semester: SEM1
Originating Department: Biological Sciences
Pre-requisites: N/A
This module will examine the molecular and biochemical processes that underlie a number of important human diseases. These diseases include common inherited diseases, diabetes, cardiovascular/neurological disorders and diseases of lipid metabolism, e.g. heart disease/stroke, atherosclerosis and obesity.

The module will also allow the student to study critically the role of oncogenes and tumour suppressor genes in the development of human cancer, including their identification, followed by a general discussion of human cancer as a disease from the pathological and molecular biological viewpoints including concepts of progression and metastasis.

Learning outcomes 
At the end of this module students will acquire knowledge and critical understanding of the principles of:

A. How metabolic disorders can lead to diabetes and hypertension.

B. How protein defects can lead to genetic diseases, heart failure and potentially to neurological diseases.

C. How problems in lipid metabolism can cause disease and the treatments.

D. The concept of progression from the normal to the cancerous state and the mechanisms that contribute to the progression.

E. How the principles established using experimental systems can be applied to understanding the development of human diseases, cancer and their treatment.

They will also understand how these principles have been developed and applied to other areas of biology, and know the methods and appropriate approaches required to solve problems in this area.

Method of teaching and learning 
Course content will be delivered primarily via standard lectures and tutorials that will be accompanied by suitable lecture handouts. Students will also be guided to sections of specific textbooks and/or reading of specific reviews.
Topic 1 Molecular foundations of monogenetic diseases.

Topic 2 Metabolic disorders. Diabetes.

Topic 3 Obesity and energy homeostasis.

Topic 4 Cardiovascular disorders. Hypertension. Renin, angiotensin, aldosterone, ACE, ACE inhibitors, angiotensin receptors.

Topic 5 Cardiomyopathies. Cardiac hypertrophy and dilated cardiomyopathy.

Topic 6 Neurological disorders. Post-translational modification of proteins and diseases. Prions and TSEs.

Topic 7 Neurological disorders: Alzheimer's disease.

Topic 8 Introduction and overview. Diversity of lipids and lipid-related disease: Cholesterol and coronary heart disease/stroke; the steroid hormones; eicosanoids in inflammatory disease and sphingolipids.

Topic 9 Cholesterol: A central lipid in health and disease. Synthesis and regulation of cholesterol.

Topic 10 Lipid trafficking in the body. Lipoproteins, defects in lipoprotein metabolism and dyslipidemias.

Topic 11 Abnormalities in lipid metabolism and the disease mechanisms of atherosclerosis.

Topic 12 Sphingolipids and disease.

Topic 13 Introduction of cancer and the hallmarks of cancer

Topic 14 Tumour viruses

Topic 15 Oncogenes

Topic 16 Growth factors and their receptors.

Topic 17 Regulation of cell growth

Topic 18 Anti-oncogenes and tumour suppressor genes

Topic 19 Genomic stability and cancer (DNA damage, repair and cancer)

Topic 20 p53 and apoptosis

Topic 21 Tumour angiogenesis and metastasis.

Topic 22 Stem cells and differentiation. Hormones and cancer. Animal models of cancer.

Delivery Hours  
Lectures Seminars Tutorials Lab/Prcaticals Fieldwork / Placement Other(Private study) Total
Hours/Semester 26    10      114  150 


Sequence Method % of Final Mark
1 Final Exam 85.00
2 Continuous 15.00

Module Catalogue generated from SITS CUT-OFF: 6/7/2020 4:44:56 AM