Module Catalogues, Xi'an Jiaotong-Liverpool University   
Module Code: BIO302
Module Title: Biochemical Messengers
Module Level: Level 3
Module Credits: 5.00
Academic Year: 2019/20
Semester: SEM2
Originating Department: Biological Sciences
Pre-requisites: N/A
The module will examine how cells and organisms respond to external signals and how signalling information is transferred within cells and organisms. The range of different strategies for dealing with signalling information will be investigated in detail. All the events involved in the transfer of signalling information from an occupied receptor on the cell surface to changes in gene expression in the cell nucleus and the outputs at the organism level will be discussed in detail.
Learning outcomes 
A. The range of different mechanisms utilised for the transfer of signalling information within eukaryotic cells.

B. The fundamental concepts and features underlying different signalling mechanisms.

C. The evaluation of the contributions made by specific signalling mechanisms in different cellular and physiological responses.

D. They will also acquire the ability to apply, critically evaluate and interpret this knowledge to solve complex problems in Biology. They will also be able to review evidence to support conclusions.

Method of teaching and learning 
Course content will be delivered primarily via standard lectures, that will be accompanied by suitable lecture handouts. Students will also be guided to sections of specific textbooks and/or reading of specific reviews.
Lecture topics

• Review of material covered in Cell Signalling (BIO208)

• Cell surface receptors

• Consequences of receptor occupancy

• G proteins

• Cyclic nucleotides: adenylyl cyclase-cAMP-PKA

• Inositol phospholipid turnover and Ser/Thr protein

• Receptor tyrosine kinase

• Protein cascades of MAPK pathways

• Calcium mobilization and intracellular signalling

• Calcium-dependent intracellular signalling: function and roles of CamKs

• Use of model organisms to study signal transduction

• Developmental pathways controlled by signal transduction

• Roles of Notch signaling in development

• Roles of RTK signaling in development

• Roles of Wnt signaling in development

• Roles of Hedgehog signaling in development

• Roles of TGF-beta signaling in development

• Control of body and tissue size by signal transduction

• Control of cell movement by signal transduction

• Left-Right asymmetric formation by signal transduction
Delivery Hours  
Lectures Seminars Tutorials Lab/Prcaticals Fieldwork / Placement Other(Private study) Total
Hours/Semester 26     10      114  150 


Sequence Method % of Final Mark
1 Final Exam 70.00
2 Continuous Assessment 1 15.00
3 Continuous Assessment 2 15.00

Module Catalogue generated from SITS CUT-OFF: 5/23/2019 5:40:52 AM