This module will examine the molecular and biochemical processes that underlie a number of important human diseases. These diseases include common inherited diseases, diabetes, cardiovascular/neurological disorders and diseases of lipid metabolism, e.g. heart disease/stroke, atherosclerosis and obesity.
The module will also allow the student to study critically the role of oncogenes and tumour suppressor genes in the development of human cancer, including their identification, followed by a general discussion of human cancer as a disease from the pathological and molecular biological viewpoints including concepts of progression and metastasis.
At the end of this module students will acquire knowledge and critical understanding of the principles of:
A. How metabolic disorders can lead to diabetes and hypertension.
B. How protein defects can lead to genetic diseases, heart failure and potentially to neurological diseases.
C. How problems in lipid metabolism can cause disease and the treatments.
D. The concept of progression from the normal to the cancerous state and the mechanisms that contribute to the progression.
E. How the principles established using experimental systems can be applied to understanding the development of human diseases, cancer and their treatment.
They will also understand how these principles have been developed and applied to other areas of biology, and know the methods and appropriate approaches required to solve problems in this area.
Course content will be delivered primarily via standard lectures and tutorials that will be accompanied by suitable lecture handouts. Students will also be guided to sections of specific textbooks and/or reading of specific reviews.