This module aims to provide students with a comprehensive understanding of cellular biology and molecular biology, which is fundamental to many areas of biological studies, particularly in the context of pharmacology. It emphasizes the information processing pathways within the cell that lead to the expression of genetic information encoded in DNA, which is crucial for drug discovery and development. The cellular biology part of this module introduces students to a range of core concepts relating to the structure and function of eukaryotes and prokaryotes. It addresses both the important components of the cell and their role in the context of diverse biological phenomena, including growth and development, division and signaling, thereby integrating important aspects of physiology, pharmacology, biochemistry and genetics to understand the mechanisms of drug action and resistance. The molecular biology part of this module introduces the structures and functions of the major components involved in genetic information processing pathways; proteins and nucleic acids, will be explained. DNA replication and its mutation, transcription and translation and how gene expression is regulated will be introduced. This knowledge is essential for understanding how drugs can modulate gene expression and for the development of targeted therapies.
A. define key features of prokaryotes and eukaryotes, including morphology and composition of the major cell components. B. explain the interplay of selected cellular components and their roles in cellular behaviour and cell-cell interactions. C. define essential elements of protein and nucleic acid structure and understand the mechanisms of synthesis of DNA, RNA and proteins. D. define key concepts relating to DNA mutation and DNA repair. E. describe key principles relating to gene expression and the regulation thereof. F. apply, evaluate and interpret this knowledge to solve problems in drug discovery, action and drug resistance.
The module content will be delivered primarily via standard lectures that will be accompanied by suitable lecture handouts (also available on the Learning Mall Online). At intervals during the module, tutorials and revisions will aid student’s understanding and allow the students to self-assess their understanding of the course.